158 DIFFERENCES IN BONE FORMATION WITH CARTILAGE LOSS DETERMINES OSTEOARTHRITIC SUSCEPTIBILITY

Quantitative bone marrow lesion size in osteoarthritic knees correlates with cartilage damage and predicts longitudinal cartilage loss

BACKGROUND Bone marrow lesions (BMLs), common osteoarthritis-related magnetic resonance imaging findings, are associated with osteoarthritis progression and pain. However, there are no articles describing the use of 3-dimensional quantitative assessments to explore the longitudinal relationship between BMLs and hyaline cartilage loss. The purpose of this study was to assess the cross-sectional ...

Cartilage in osteoarthritic joints is not automatically osteoarthritic cartilage.

Interactions between subchondral bone and cartilage in OA. Cells from osteoarthritic bone can alter cartilage metabolism.

Formation of calcium phosphate crystals in normal and osteoarthritic cartilage.

The mechanism of cartilage calcification has been outlined in recent reviews."' A study of epiphyseal cartilage calcification has clearly established that the first crystals of apatite that are found in the hypertrophic zone are found in matrix vesicles, in the longitudinal septa.' 2 Matrix vesicles are extracellular, membranous particles, about 100 nm in diameter, that are associated with calc...

Knee meniscal extrusion in a largely non-osteoarthritic cohort: association with greater loss of cartilage volume

We conducted a longitudinal study (duration 2 years), including 294 individuals (mean age 45 years, 58% female), in order to examine associations between meniscal extrusion, knee structure, radiographic changes and risk factors for osteoarthritis (OA) in a largely non-osteoarthritic cohort. Meniscal extrusion, tibiofemoral cartilage defect score and cartilage volume, and tibial plateau bone are...